This describes why 1 lorazepam dose, Regardless of its shorter serum 50 %-lifetime, has much more extended peak effects than an equal diazepam dose.[ninety nine] Lorazepam is rapidly conjugated at its 3-hydroxy team into lorazepam glucuronide that is then excreted inside the urine. Lorazepam glucuronide has no demonstrable CNS exercise in animals.
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